Original Papers Articles

Original Papers

Bubble technology is expected to be applied not only for cleaning and sterilization, but also in the field of medicine to extract active ingredients and deliver objects to target organs.
This section introduces the current status of bubbles, which are attracting attention around the world, as well as the results of tests.

Original Research Article] “Bio-Safety of “NanoGAS Water” for Long-Term Drinking” has been published.

2023/3/20

Morishita R, Shimada M, Nagao M, Shimizu S, Kamei N, Takeda-Morishita M. In Vivo Proof of Biological Safety and Physiological Effects of Orally Ingested In Vivo Proof of Biological Safety and Physiological Effects of Orally Ingested H2-Filled Ultrafine Bubbles (UFBs). Biol Pharm Bull. 2023;46(2):343-347.https://www.jstage.jst.go.jp/article/bpb/46/2/46_b22-00631/_article [Background and Purpose] Due to their special physicochemical properties and diverse biological effects, microbubbles have recently been exploited for industrial and biological purposes. Therefore, in this study, we decided to verify the safety of microbubbles on living organisms with a view to their future use in the health science field. In this study, H2NanoGAS®, which can retain hydrogen in liquid for a long time, was used,...

Original Research Article: “Suspension Sterilization Effect of NanoGAS” was published.

2023/3/18

Morishita R, Itoh S, Takeda-Morishita M. Evaluation of Bactericidal Effects of H2- and O3-filled Ultrafine Bubbles Water. Biocontrol Sci. 2022;27(3):139-142.https://www.jstage.jst.go.jp/article/bio/27/3/27_139/_article/-char/ja Background and PurposeIt has been shown that microbubbles have a bactericidal effect, but the relationship between the bactericidal effect and the gas species enclosed in the microbubbles has not yet been clarified.In particular, the sterilizing effect of microbubbles containing hydrogen, which has an antioxidant effect, has not been confirmed.Therefore, we have conducted a bacterial suspension test to investigate the bactericidal effect of hydrogen-filled NanoGAS water ( H2 NanoGAS water) and ozone-filled NanoGAS water (O3 NanoGAS water), both of which have bactericidal effects, and observed changes over time in the bacterial...

Original Research Article] An article has been published in “Nutrients”.

2021/9/24

An article by Dr. Zen Tanaka, President of the Intestinal Flora Transplantation Clinical Research Association ( Nutrients ), was published in “Nutrients. In the paper, the usefulness of gut flora transplantation (NanoGAS®-FMT) using NanoGAS®︎ water, which is employed in our study group, as one of the methods to optimize gut bacteria, is also described. Optimizing nutrients, digestive capacity, and immunity is important to reduce the risk of cancer, but to do so, he said, it is more important to first optimize the bacteria in the gut. It is Open Access, so anyone can read it. Please take a moment to read it.

ORIGINAL ARTICLE] A PAPER EXAMINING THE USEFULNESS OF UFB IN INTESTINAL FLORA TRANSPLANTATION HAS BEEN PUBLISHED.

2020/9/7

We are pleased to announce that our paper on the usefulness of UFB in FMT has been submitted to the journal Bioactive Compounds In Health And Disease and has been successfully accepted.It is open access, so anyone can read the full text for free. We have come this far believing that the use of UFB water (ultra fine bubble water) as well as saline as a solvent is a good way to increase the response rate of intestinal flora transplantation (stool transplantation, FMT).Although clinical cases have come along, basic research has not progressed well, but now basic research is finally catching up. It may seem...